Dual Action Pharmadynamic Testosterone Technology
Increases Testosterone Over 10,000 pg/mL**
2 Powerful Compounds Featuring 7-Arimatase™ and Dihydrotase™
Methyl ARIMATEST represents a major breakthrough in testosterone optimization, featuring dual anti-aromatase and 5 alpha-reductase inhibition. The ingredients in this powerful formula have been shown to increase testosterone to over 10,000 pg/mL.**
Compelling new research reveals a more effective way to increase testosterone levels based on a triad of intricate factors: multi-pathway physiological testosterone optimization; methylation techniques for enhanced bio-effectiveness and the application of an advanced bioactive delivery system technology.
Dual Action Testosterone Optimization Innovation
The key technological developments leading to Methyl ARIMATEST’s advanced Dual Action Testosterone Optimization mode of action were elucidated through MuscleMeds analysis and evaluation of the metabolic fate of testosterone in the body and how to optimize testosterone levels and its duration of muscle building anabolic activity. Once produced in the body, testosterone has 3 primary fates:
To add another dimensional component to this biochemical web of metabolic events, estradiol levels actually serve as a negative feedback signal to reduce luteinizing hormone production, which in turn reduces testosterone production. The implication to this hormonal balancing act means that taking typical one dimensional testosterone boosting products that focus solely on just elevating testosterone levels can often result in higher estradiol/estrogen levels. (Yes, we are talking about the female hormone.) High estradiol brings with it negative side effects like gynocomastia, increased body fat and water retention. What many people don’t know is high estrogen levels also shut down testosterone production. So, you can end up with high estrogen and low testosterone — not exactly the muscle building anabolic environment you are looking for! Therefore, what the MuscleMeds research team wanted to focus on was creating a multi-dimensional product that would include lower estradiol levels to keep testosterone production going strong.
Achieving higher testosterone and a favorable testosterone-to-estrogen ratio (T:E) through natural means is a far different ball game than taking synthetic hormones or prohormones. However, thanks to some key discoveries and new novel ingredients, this is now possible with Methyl ARIMATEST. Methyl ARIMATEST’s formula features a newly developed clinically tested Dihydrotase 5 alpha-reductase inhibiting complex, plus the new advanced potent methylated anti-aromatase 7-Arimatase. This Dual Action Testosterone Optimizing approach is vital for regulating and optimizing key hormones that influence testosterone production and body composition, DHT and estrogen.
Dihydrotase Clinically Tested 5 Alpha-Reductase Inhibitor Testosterone Boosting Study Results
The Dihydrotase complex used in Methyl ARIMATEST was tested in an independent clinical research study, which reported significant elevations in testosterone levels and decreased levels of dihydrotesosterone (DHT). Healthy males were recruited for this
Aromatase Inhibitors – Lower Estrogen and Boost Testosterone
Another mode of action in testosterone optimization is the use of aromatase inhibitors. Circulating estrogens in the body can be decreased by inhibition of their biosynthesis from testosterone. The metabolic target of estrogen synthesis inhibition is aromatase enzymes. Aromatase enzymes are part of the body’s biochemistry system that are used in the conversion of testosterone to estrogen. So, when aromatase enzyme activity is inhibited (blocked), this prevents conversion of testosterone into estrogen. For this central role in the production of estrogen, aromatase has become a central enzyme target of inhibition for people who want to optimize their testosterone levels and minimize estrogen levels.
Aromatase inhibitors have been used extensively by the medical community as a means to reduce the amount of estrogen that is produced in the body from testosterone. Research studies have reported benefits in men using aromatase inhibitors, demonstrating lower estrogen levels and simultaneously causing an increase in testosterone levels. Therefore, the use of aromatase inhibitors have become common among bodybuilders and other strength athletes who want to maintain highest testosterone levels for maximum anabolic muscle-building effects, while reducing their estrogen levels.
Independent research conducted using aromatase inhibiting substances has reported consistent results for improving testosterone level status among men of all ages. In addition to preserving testosterone levels by blocking the aromatase enzyme conversion to estradiol, increased luteinizing hormone (LH) levels are observed. Because LH is responsible for triggering testosterone production, higher LH levels are directly related to promoting higher testosterone levels.
The effects of Aromatase inhibitor on testosterone production is likely mediated by the reduction in estradiol production. Reducing estradiol production from testosterone reduces estradiol’s negative feedback on the pituitary and hypothalamus glands, preventing the “shut down” of testosterone production. Aromatase inhibitors appear to stimulate pituitary LH secretion sufficiently to cause an increase of endogenous testosterone production.
It is interesting to note that aromatase inhibitors have been given to men of various ages in several studies. In these studies, similar changes in gonadal steroid hormone levels were generally observed. In one noteworthy study of eugonadal elderly men who were given just 2 mg of aromatase inhibitors daily for 9 weeks, researchers reported that blood levels of estradiol decreased by 29% and total testosterone levels increased by an incredible 56%.
FORMULA 1 (DIHYDROTASE) Directions: Take two capsules in the morning and two capsules in the evening with water.FORMULA 2 (7-ARIMATASE) Directions: Place one SubZorb tablet in mouth and let dissolve completely, then swallow. For maximum effects take two Formula 2 SubZorb tablets per day: one tablet in the morning and one tablet in the evening.
For use by healthy adult males only. NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF PREGNANT OR NURSING. Consult a physician or licensed qualified healthcare professional before using this product, including, but not limited to, if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness and irritability. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision or other similar symptoms.
Science Behind Methyl Arimatest
In the development of Methyl ARIMATEST, the MuscleMeds research team knew it was paramount to inhibit the conversion of testosterone into DHT and estrogen if they were going to achieve the desired elevated and sustained levels of testosterone for maximum anabolic effects. To achieve this, MuscleMeds researchers focused on how to optimize the endogenous production of testosterone, while inhibiting negative feedback inhibition. To understand the importance of this, you must understand that the human body is a complex system of checks and balances. The production of testosterone is controlled at the hypothalamus-pituitary-testes axis. At this axis, the levels of testosterone are governed by a variety of complex signals and surges, and a negative feedback mechanism exists. This negative feedback is a physiological “turn off switch,” which shuts down testosterone production in response to trying to maintain homeostasis. Methyl ARIMATEST is scientifically formulated to override this negative feedback “off switch” to sustain testosterone production and promote the higher levels of testosterone needed to trigger “anabolically activated” muscle growth.
Key Mechanisms of Action and Compounds in Methyl ARIMATEST
DHT (Dihydrotestosterone) and 5 Alpha-Reductase Inhibition
In the body, some testosterone gets converted to DHT, which primarily exerts what is termed “androgenic effects,” such as body and facial hair growth, acne and prostate growth. Increasing testosterone levels can, therefore, lead to increasing DHT levels and androgenic effects, versus the more desirable anabolic muscle-building effects that testosterone exerts in muscle tissue. Research has shown that blocking the 5 alpha-reductase enzyme will inhibit the conversion of testosterone to DHT. Additionally, researchers have recently hypothesized that reducing testosterone’s conversion to DHT will allow more testosterone to remain in the bloodstream thereby increasing testosterone levels. To accomplish the goal of reducing the conversion of testesterone to DHT, Methyl ARIMATEST utilizes a clinically tested 5 alpha-reductase inhibitor called Dihydrotase.
7-Arimatase: A New Type of Highly Bio-Active Aromatase Inhibitor
During the MuscleMeds research team’s constant effort for creating an improved aromatase-inhibiting product, their attention was drawn to specialized naturally occurring compounds that were determined experimentally to have aromatase-inhibiting properties. As part of their product development protocol, MuscleMeds evaluated the bioavailability of the selected candidate substances. While several of these substances exhibited high aromatase-inhibiting activity, when it came to intestinal absorption and metabolic stability in the body, it was determined that there was a clear grouping of the majority of flavonoids that scored low and only a few that scored high.
When the molecular structures of these aromatase-inhibiting substances were examined closely, an interesting discovery was made. There were key characteristics of the molecular structure that were related to the substances aromatase-inhibiting activity and the bioavailability (intestinal absorption and metabolic stability in the body).
MuscleMeds used this research in their creation of the 7-Arimatase methylated flavone (7-methoxyflavone) molecule. When subjected to independent research, it was determined that 7-Arimatase (also referred to as 7-MF) had one of the highest aromatase-inhibiting scores, with high intestinal absorption and metabolic stability in the body.
This triad of characteristics is extremely important for creating the most effective aromatase inhibitor. You see, even if a substance has high aromatase-inhibiting activity, if it is poorly absorbed or unstable and metabolized quickly in the body, it will be ineffective. Therefore, out of all the substances examined by the MuscleMeds research team, 7-Arimatase was the top choice due to the triad combination of characteristics required for maximum aromatase-inhibiting activity inside the body.
Once the highly effective 7-Arimatase aromatase-inhibitor was created, the MuscleMeds research team focused its attention on determining the ideal route of oral administration. It was determined that transmucosal delivery was ideally suited for delivery of 7-Arimatase into the body. A specialized subuccal tablet was created utilizing MuscleMeds exclusive SubZorb Technology. This is the fastest route of oral delivery, as absorption takes place in the mucosal tissues of the mouth, and any residual that was not absorbed in the mouth is taken up via the digestive system. Getting 7-Arimitase into the bloodstream fast is important to synergistically maximize the testosterone levels produced by Methyl ARIMATEST’s Dihydrotase complex, while also reducing estrogen levels.