HICA-MAX™ is a powerful, non-hormonal, natural stimulator of muscle growth. Its chewables contain 100% pharmaceutical-grade leucic acid, also known as alpha-hydroxy-isocaproic acid (HICA) – a natural metabolite of the branched chain amino acid, leucine.
HICA-Max™ is one of the newest additions to the Labrada Nutrition line, and presents a new pathway to supporting muscle growth for everyone, male and female, pushing muscle to the point of breakdown during vigorous weight lifting session or power workouts. HICA-Max™ is designed to work in a catabolic environment. Recreational lifters easing through a simple circuit or group fitness class are unlikely to find benefit. Heavy lifters will benefit from this novel ingredient.
The active ingredient in HICA-Max™ is L-α-hydroxyisocaproic acid, abbreviated to HICA. Chemical nomenclature, (the system that defines proper naming of chemicals) recognizes other names for HICA, including 2-Hydroxy-4-methylpentanoic acid, 2-Hydroxy-4-methylvaleric acid, and leucic acid. HICA is a metabolite, or degradation product of leucine, the essential branched chain amino acid. The conversion rate of leucine to HICA is very small, so taking lots of leucine will not provide effective levels of HICA.
HICA-MAX™ works by increasing protein synthesis (anabolism), and decreasing muscle protein breakdown (catabolism). Its mode of action has been suggested as an independent mTOR signal transducer, which is a “cell-signaler” for muscle protein synthesis. Leucic acid also interrupts muscle protein breakdown by activating nuclear factor kappa B and inhibiting caspase-8. It may also activate IGF-1, a growth factor that helps age-related decreases in your body’s growth hormone output.
Unlike prohormones or anabolic steroids, HICA-MAX™ activates ¬anabolic and anti-catabolic pathways without directly affecting your body’s hormonal balance. HICA-MAX™ gives you maximum muscle growth without negative side effects, and you’ll never have to cycle off of it.
HICA is a metabolite of leucine, via KIC. However, leucine supplementation does not elevate blood levels of HICA. Therefore, HICA supplementation is necessary to achieve efficacious levels in muscles.
HICA binds H+ (acid) which builds up in the muscle cell as work exceeds the aerobic threshold (e.g. high-intensity lifting, sprinting).
HICA binds ammonia (NH4+) which builds up in the blood and creates fatigue.
HICA can be reaminated, providing a pool of leucine for post-workout recovery and cell-signaling.