Purus Labs® D-POL™ PowderOverview and Rationale for use
We are proud to bless the athletic masses with yet another novel, performance-enhancing product based purely on human, orally efficacious research. D-POL™ Powder combines provocative, emerging research regarding natural testosterone elicitation and nitric oxide production, to yield the industry's first, validated, dual-phasic Lutenizing Hormone/Free Testosterone elevator AND true nitric oxide potentiator.Research validates:
Activated vitamin D (calcitriol) has been referred to as a pluripotent pleiotropic secosteroid hormone (Cannell et al., 2009). As a steroid hormone regulating more than 1000 vitamin D-responsive human genes, vitamin D may influence athletic performance. As noted by Cannell and colleagues (2009) in a recent review article on the topic "physical and athletic performance is seasonal; it peaks when 25-hydroxy-vitamin D levels peak, declines as they decline, and reaches its nadir when 25-hydroxy-vitamin D levels are at their lowest." These findings are underscored by the potential impact that vitamin D has on skeletal muscle, as described recently (Bartoszewska et al., 2010; Ceglia, 2009; Hamilton, 2010). Furthermore, a recent study (Pilz et al., 2011) in healthy men who supplemented with 3332 IU of vitamin D daily for one year, noted a significant increase in total, bioactive, and free testosterone levels. Considering the well-described health effects of vitamin D, coupled with the potential impact of vitamin D on exercise performance, supplementation with this powerful vitamin should be considered by all individuals.
Research indicates that vitamin D toxicity is very unlikely in healthy individuals when used at amounts less than 10,000 IU/day (Vieth, 1999). However, the Food and Nutrition Board of the Institute of Medicine (IOM) and a recent Clinical Practice Guideline from the IOM in conjunction with the Endocrine Society (Holick et al., 2011) has set a conservative tolerable upper intake level of 4,000 IU/day (100 mcg/day) for all adults. This is similar to the dosage used in many clinical trials and is the dosage provided within D-POL™.
Cofactors for Vitamin D
For optimal vitamin D absorption, taking vitamin D with the largest meal of the day seems most appropriate (Mulligan & Licata, 2010). Beyond this, it has been suggested that certain vitamin and mineral cofactors are potentially needed for optimal vitamin D action and effect. However, it should be noted that the need for these cofactors is debatable. Moreover, most of these co-factors are present in vitamin/mineral supplements, which most individuals consume regularly. The cofactors of interest include magnesium, zinc, vitamin K2, vitamin A, and boron. With regards to boron, aside from acting as a cofactor for vitamin D, one recent report indicates a testosterone elevating effect of this mineral (Naghii et al., 2010). It is possible that this may enhance the action of DAA on circulating testosterone. However, an earlier report for boron refutes these findings (Green and Ferrando, 1994). Collectively considering the above, boron and other co-factors are not included within d-pol™.SUMMARY
D-POL™ Powder contains a carefully selected blend of ingredients, based on human evidence for oral effect in relation to multiple aspects of health and performance. Increased natural testosterone synthesis and TRUE nitric oxide production via a secondary entero-salivary pathway elicits unbridled muscle growth, enhanced recovery, oxygen sparing effects (mitochondrial efficiency), increased exercise duration, and enhanced nutrient absorption. This is a dual-phasic product perfectly tailored for the strength/power or endurance athlete.
Aside from the myriad of positive metabolic effects B vitamins have, of greatest importance in relation to the use of these vitamins within D-POL™, these B-vitamins have been used in combination with DAA for purposes of elevating circulating testosterone: B9 (folic acid), B6 (pyridoxine), and B12 (cyanocobalamin). Because dietary folic acid is not well metabolized to the active form by some individuals due to a genetic defect within the folate pathway, the naturally occurring form of this vitamin (folate) is included within D-POL™.